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JX-078

Chemical Structure : JX-078

CAS No.: 3010898-81-1

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JX-078 (JX078)

Catalog No.: PC-25184Not For Human Use, Lab Use Only.

JX-078 is a potent, selective inhibitor of L-type amino acid transporters LAT1 (SLC7A5), inhibits [3H]-L-leucine uptake into HT-29 cells with IC50 of 121 nM, >10-fold selective over in LAT2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JX-078 is a potent, selective inhibitor of L-type amino acid transporters LAT1 (SLC7A5), inhibits [3H]-L-leucine uptake into HT-29 cells with IC50 of 121 nM, >10-fold selective over in LAT2.
JX-078 induces differential metabolomic changes in human PBMCs upon incubation in blood.
JX-078 induces significantly different metabolomic changes in LAT1-expressing cells.
JX-078 exerts antiproliferative effects in cancer cells independent of LAT1.

Physicochemical Properties

M.Wt 373.45
Formula C24H23NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-([1,1'-biphenyl]-2-ylmethoxy)-2-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

References

1. Yan R, et al. Cell Discov. 2021 Mar 23;7(1):16.

2. Morozova V, et al. Biomed Pharmacother. 2025 Jul 31;190:118402.

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