7-alpha-hydroxycholesterol | TCR inhibitor

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Chemical Structure : 7-alpha-hydroxycholesterol

CAS No.: 566-26-7

7-alpha-hydroxycholesterol (7a-HC)

Catalog No.: PC-22368Not For Human Use, Lab Use Only.

7alpha-hydroxycholesterol (7a-HC) is the 7alpha-hydroxy derivative of cholesterol, is a potent inhibitor of TCR signaling and promotes membrane binding of CD3ε cytoplasmic domain.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$348	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

7alpha-hydroxycholesterol (7a-HC) is the 7alpha-hydroxy derivative of cholesterol, is a potent inhibitor of TCR signaling and promotes membrane binding of CD3ε cytoplasmic domain.

Physicochemical Properties

M.Wt	402.66
Formula	C27H46O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,7S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol

References

1. Zhengxu Ren, et al. Cell Chem Biol. 2024 May 16;31(5):920-931.e6.

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7-alpha-hydroxycholesterol (7a-HC)

Biological Activity

Physicochemical Properties

References

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