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Chemical Structure : ML281
CAS No.: 1404437-62-2
Catalog No.: PC-22384Not For Human Use, Lab Use Only.
ML281 is a potent, selective inhibitor of serine/threonine kinase STK33 with IC50 of 14 nM, >500-fold selective over PKA and AurB.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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ML281 is a potent, selective inhibitor of serine/threonine kinase STK33 with IC50 of 14 nM, >500-fold selective over PKA and AurB.
ML281 also displays clean selectivity against a panel of 83 kinases chosen for diversity and toxicity.
ML281 does not appear to significantly alter viability at 10 uM for KRAS-dependent (NOMO-1 and SKM-1) and KRAS-independent (THP-1 and U937) AML-derived cell lines.
| M.Wt | 389.47 | |
| Formula | C22H19N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-Isopropyl-2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)thiophene-2-carboxamide |
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1. Weïwer M, et al. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038.
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