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Chemical Structure : UCF-101
CAS No.: 313649-08-0
Catalog No.: PC-22416Not For Human Use, Lab Use Only.
UCF-101 is a specific inhibitor for the pro-apoptotic protease Omi/HtrA2 with IC50 of 9.5 uM, displays high selectivity over other serine proteases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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UCF-101 is a specific inhibitor for the pro-apoptotic protease Omi/HtrA2 with IC50 of 9.5 uM, displays high selectivity over other serine proteases.
UCF-101 restores heart dysfunction following ischemia/reperfusion injury in vivo.
UCF-101 prevented loss of membrane integrity by inhibiting fodrin breakdown in cardiomyocytes.
UCF-101 rescues cardiomyocytes from ischemia/reperfusion injury by inhibiting XIAP degradation and Fas/Fas-ligand-induced apoptosis, thereby ameliorating ischemia/reperfusion-induced myocardial dysfunction.
| M.Wt | 495.51 | |
| Formula | C27H17N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione |
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1. Bhuiyan MS, et al. Eur J Pharmacol. 2007 Feb 28;557(2-3):168-77.
2. Cilenti L, et al. J Biol Chem. 2003 Mar 28;278(13):11489-94
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