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UCF-101

Chemical Structure : UCF-101

CAS No.: 313649-08-0

UCF-101 (UCF101, ucf-101)

Catalog No.: PC-22416Not For Human Use, Lab Use Only.

UCF-101 is a specific inhibitor for the pro-apoptotic protease Omi/HtrA2 with IC50 of 9.5 uM, displays high selectivity over other serine proteases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UCF-101 is a specific inhibitor for the pro-apoptotic protease Omi/HtrA2 with IC50 of 9.5 uM, displays high selectivity over other serine proteases.
UCF-101 restores heart dysfunction following ischemia/reperfusion injury in vivo.
UCF-101 prevented loss of membrane integrity by inhibiting fodrin breakdown in cardiomyocytes.
UCF-101 rescues cardiomyocytes from ischemia/reperfusion injury by inhibiting XIAP degradation and Fas/Fas-ligand-induced apoptosis, thereby ameliorating ischemia/reperfusion-induced myocardial dysfunction.

Physicochemical Properties

M.Wt 495.51
Formula C27H17N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

References

1. Bhuiyan MS, et al. Eur J Pharmacol. 2007 Feb 28;557(2-3):168-77.

2. Cilenti L, et al. J Biol Chem. 2003 Mar 28;278(13):11489-94

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