Chemical Structure : LW-216
Catalog No.: PC-22430Not For Human Use, Lab Use Only.
LW-216 is a novel specific small molecule thioredoxin reductase 1 (TrxR1, TXNRD1) inhibitor directly binds TrxR1 (KD of 8.8 uM in MST assays) and persistently promotes TrxR1 ubiquitination, inhibits TrxR1 expression.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LW-216 is a novel specific small molecule thioredoxin reductase 1 (TrxR1, TXNRD1) inhibitor directly binds TrxR1 (KD of 8.8 uM in MST assays) and persistently promotes TrxR1 ubiquitination, inhibits TrxR1 expression.
LW-216 concentration-dependently reduces TrxR1 expression in both NCI-H460 and A549 cells, while TrxR2 expression remaines unaffected.
LW-216 promotes TrxR1 ubiquitination by binding at R371 and G442 sites.
LW-216 induces mitochondrial-mediated apoptosis in non-small cell lung cancer cells.
LW-216 triggers ROS-dependent apoptosis which can be reversed by TrxR1 expression.
LW-216 (8 mg/kg) inhibited tumor growth of NCI-H460 cells in xenograft mice model, with minimal impact on the body weight of the animals.
M.Wt | 485.58 | |
Formula | C30H31NO5 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
1. Wang R, et al. Neoplasia. 2024 Jul;53:101004.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright