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Chemical Structure : JNJ-74856665
Catalog No.: PC-49779Not For Human Use, Lab Use Only.
JNJ74856665 (JNJ74856665) is an orally available, potent and selective DHODH inhibitor with IC50 of 0.4 nM.
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JNJ74856665 (JNJ74856665) is an orally available, potent and selective DHODH inhibitor with IC50 of 0.4 nM.
JNJ74856665 inhibited proliferation of MOLM-13, OCI-AML3, HL60 and THP-1 AML cell lines with low nanomolar IC50 values in vitro, demonstrated induction of CD11b and CD14 differentiation marker mRNA levels in four cell lines.
JNJ-74856665 mediated significant activity in decreasing leukemic burden and increasing life span across subcutaneous (MOLM-13 and OCI-AML3) and disseminated (MOLM-13) xenografts, respectively, in vivo.
| M.Wt | 436.49 | |
| Formula | C24H25FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patent WO2021084500 A1.
2. DeRatt LG, et al. J Med Chem. 2024 Jul 11;67(13):11254-11272.
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