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CNS-11g

Chemical Structure : CNS-11g

CAS No.: 1309162-57-9

CNS-11g

Catalog No.: PC-49767Not For Human Use, Lab Use Only.

CNS-11g is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CNS-11g is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core.
    CNS-11g is more predictive of oral bioavailability and central nervous system penetration compared to EGCG.
    CNS-11g (10 uM) inhibits intracellular seeding in alpha-synuclein biosensor cells and mitigation of alpha-synuclein cytotoxicity.
    CNS-11g disaggregates MSA patient brain-derived alpha-synuclein fibrils in vitro, reduces alpha-synuclein aggregates in C. elegans, also could penetrate brain tissue in mice.

    Physicochemical Properties

    M.Wt 411.51
    Formula C26H25N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(4-benzyl-1-oxophthalazin-2(1H)-yl)-N-mesitylacetamide

    References

    1. Murray KA, et al. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2217835120.

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