Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CD80 inhibitor 1
CAS No.: 486449-65-4
Catalog No.: PC-22886Not For Human Use, Lab Use Only.
CD80 inhibitor 1 is a specific small molecule inhibitor of human CD80 with SPR KD of 125 nM, antagonize CD28 (TR_FRET EC50=630 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CD80 inhibitor 1 is a specific small molecule inhibitor of human CD80 with SPR KD of 125 nM, antagonize CD28 (TR_FRET EC50=630 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays.
| M.Wt | 323.28 | |
| Formula | C17H10FN3O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(6-Fluoro-3-oxo-3,5-dihydro-2H-pyrazolo[4,3-c]quinolin-2-yl)benzoic acid |
|
1. Philip Huxley, et al. Chem Biol. 2004 Dec;11(12):1651-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
