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NAT1 inhibitor Cmp350

Chemical Structure : NAT1 inhibitor Cmp350

CAS No.:

NAT1 inhibitor Cmp350

Catalog No.: PC-22918Not For Human Use, Lab Use Only.

NAT1 inhibitor Cmp350 is a potent small molecule inhibitor of arylamine N-acetyltransferase 1 (NAT1) with IC50 of 44 nM, inhibits mitochondrial respiration and alters mitochondrial metabolism in MDA-MB-231 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NAT1 inhibitor Cmp350 is a potent small molecule inhibitor of arylamine N-acetyltransferase 1 (NAT1) with IC50 of 44 nM, inhibits mitochondrial respiration and alters mitochondrial metabolism in MDA-MB-231 cells.
NAT1 inhibitor Cmp350 decreases basal respiration and reserve respiratory capacity without affecting ATP production.
NAT1 inhibitor Cmp350 shows excellent inhibition in cells up to 100 μM without toxicity.
NAT1 inhibitor Cmp350 decreases maximum respiration rates in a reversible manner.

Physicochemical Properties

M.Wt 462.48
Formula C24H18N2O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4-((1,4-dioxo-3-(phenylsulfonamido)-1,4-dihydronaphthalen-2-yl)amino)phenyl)acetic acid

References

1. Choudhury C, et al. ACS Pharmacol Transl Sci. 2024 Jul 17;7(8):2326-2332.

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