XM462 | Dihydroceramide desaturase inhibitor

Chemical Structure : XM462

XM462 (XM-462)

Catalog No.: PC-26799Not For Human Use, Lab Use Only.

XM462 is a small molecule inhibitor of dihydroceramide desaturase (Des1) with IC50 of 8.2 uM and Ki of 2 uM, inhibits sphingolipid synthesis, triggers autophagy and reduces amyloid secretion by neurons.

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Biological Activity

Physicochemical Properties

M.Wt	445.75
Formula	C25H51NO3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((2S,3S)-1,3-dihydroxy-4-(tridecylthio)butan-2-yl)octanamide

References

1. Munoz-Olaya JM, et al. ChemMedChem. 2008 Jun;3(6):946-53.

2. Ordóñez-Gutiérrez L, et al. Pharm Res. 2018 Feb 6;35(3):49.

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XM462 (XM-462)

Biological Activity

Physicochemical Properties

References

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