CNT2198 | DES1 inhibitor | Probechem Biochemicals

Chemical Structure : CNT2198

CNT2198 (CNT-2198)

Catalog No.: PC-26802Not For Human Use, Lab Use Only.

CNT2198 is a potent, selective dihydroceramide desaturase 1 (DES1) inhibitor, lowers renal ceramides, increases dihydroceramides, and shifts complex sphingolipid saturation without evidence of off-target effects.

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Biological Activity

Physicochemical Properties

M.Wt	367.33
Formula	C16H16F3N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-hydroxypyridin-2-yl)-4-(6-(trifluoromethyl)pyridin-3-yl)piperazine-1-carboxamide

References

1. Nicholson RJ, et al. Cell Metab. 2026 Jan 6;38(1):135-156.e10.

2. Patent US-20200339535-A1.

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CNT2198 (CNT-2198)

Biological Activity

Physicochemical Properties

References

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