HMGCS1 inhibitor CNP7

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Chemical Structure : HMGCS1 inhibitor CNP7

Catalog No.: PC-26814Not For Human Use, Lab Use Only.

CNP7 is a potent, selective, covalent HMG-CoA synthase 1 (HMGCS1) inhibitor, reduces HMG-CoA levels and global protein prenylation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CNP7 is a potent, selective, covalent HMG-CoA synthase 1 (HMGCS1) inhibitor, reduces HMG-CoA levels and global protein prenylation.
CNP7 engages the catalytic cysteine Cys129 within HMGCS1′s hydrophobic pocket.
CNP7 (5 uM) reduces cellular HMG-CoA levels and global protein prenylation in HCT116 cells.
CNP7 (5 uM) inhibits cell proliferation by disrupting geranylgeranyl pyrophosphate metabolism in HCT116 cells.

Physicochemical Properties

M.Wt	386.46
Formula	C23H22N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-cyano-N-((3'-(prop-2-yn-1-ylcarbamoyl)-[1,1'-biphenyl]-3-yl)methyl)pyrrolidine-3-carboxamide

References

1. Sun L, et al. J Am Chem Soc. 2026 May 13. doi: 10.1021/jacs.6c02556.

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