BI-0115 | LOX-1 inhibitor | Probechem Biochemicals

Chemical Structure : BI-0115

CAS No.: 4929-23-1

BI-0115 (BI0115, BI 0115)

Catalog No.: PC-26812Not For Human Use, Lab Use Only.

BI-0115 is a selective small molecule inhibitor of lectin-like oxidized LDL receptor-1 (LOX-1) with IC50 of 5.4 uM, blocks cellular uptake of oxidized low-density lipoproteins (oxLDL).

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
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Biological Activity

BI-0115 is a selective small molecule inhibitor of lectin-like oxidized LDL receptor-1 (LOX-1) with IC50 of 5.4 uM, blocks cellular uptake of oxidized low-density lipoproteins (oxLDL).
BI-0115 triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain.

Physicochemical Properties

M.Wt	287.75
Formula	C15H14ClN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-Chloro-5-propyl-5,11-dihydro-6H-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one

References

1. Schnapp G, et al. Commun Chem. 2020 Jun 10;3(1):75.

2. Arkelius K, et al. Circ Res. 2024 Apr 12;134(8):954-969.

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BI-0115 (BI0115, BI 0115)

Biological Activity

Physicochemical Properties

References

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