Catalog No.: PC-20305Not For Human Use, Lab Use Only.
ELOVL6 inhibitor 37 (ELOVL6-IN-2) is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 8.9 and 31 nM for human and mouse ELOVL6, respectively.
ELOVL6 inhibitor 37 (ELOVL6-IN-2) is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 8.9 and 31 nM for human and mouse ELOVL6, respectively.
ELOVL6 inhibitor 37 weakly inhibits hELOVL3 (IC50=337 nM), and does not inhibit hELOVL1, hELOVL2 and hELOVL5 (IC50>10 uM).
ELOVL6 inhibitor 37 (0.1, 0.3, and 1 mg/kg, 0.5% methylcellulose, oral) potently and dose-proportionally suppressed the elongation index in the liver in mice.
