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ELOVL6 inhibitor 37

Chemical Structure : ELOVL6 inhibitor 37

CAS No.: 1067647-43-1

ELOVL6 inhibitor 37 (ELOVL6-IN-2)

Catalog No.: PC-20305Not For Human Use, Lab Use Only.

ELOVL6 inhibitor 37 (ELOVL6-IN-2) is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 8.9 and 31 nM for human and mouse ELOVL6, respectively.

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Biological Activity

ELOVL6 inhibitor 37 (ELOVL6-IN-2) is a potent, selective inhibitor of elongase of long-chain fatty acids family 6 (ELOVL6) with IC50 of 8.9 and 31 nM for human and mouse ELOVL6, respectively.
ELOVL6 inhibitor 37 weakly inhibits hELOVL3 (IC50=337 nM), and does not inhibit hELOVL1, hELOVL2 and hELOVL5 (IC50>10 uM).
ELOVL6 inhibitor 37 (0.1, 0.3, and 1 mg/kg, 0.5% methylcellulose, oral) potently and dose-proportionally suppressed the elongation index in the liver in mice.

Physicochemical Properties

M.Wt 579.50
Formula C28H23F6N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5,5-dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione

References

1. Toshiyuki Takahashi, et al. J Med Chem. 2009 May 28;52(10):3142-5.

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