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Indoluidin D

Chemical Structure : Indoluidin D

CAS No.: 2763081-61-2

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Indoluidin D

Catalog No.: PC-20263Not For Human Use, Lab Use Only.

Indoluidin D is a potent selective dihydroorotate dehydrogenase (DHODH) inhibitor, promotes myeloid differentiation and inhibits the proliferation of acute promyelocytic leukemia HL-60 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Indoluidin D is a potent selective dihydroorotate dehydrogenase (DHODH) inhibitor, promotes myeloid differentiation and inhibits the proliferation of acute promyelocytic leukemia HL-60 cells.
    Indoluidin D also suppresses cell growth in various other types of cancer cells.
    Indoluidin D inhibits human DHODH activity in vitro.
    The DHODH reaction product orotic acid can rescue indoluidin D-induced cell differentiation.

    Physicochemical Properties

    M.Wt 452.56
    Formula C28H28N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-((R)-3-(1H-indol-3-yl)-1-oxo-1-(p-tolylamino)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

    References

    1. Makoto Kawatani, et al. ACS Chem Biol. 2021 Nov 19;16(11):2570-2580.

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