TGN-020 (TGN020) is a potent, selective aquaporin 4 (AQP4) inhibitor with IC50 of 3 uM.
TGN-020 significantly reduced the cortical infarct volume, with no effect on basal ganglia infarct volume.
Pretreatment with TGN-020 significantly reduced the severity of brain edema associated with brain ischemia.
TGN-020 significantly increases regional cerebral blood flow in vivo, TGN-020 can alleviate spinal cord edema, inhibit glial scar formation, and promote axonal regeneration, conferring beneficial effects on recovery in rats.
Physicochemical Properties
M.Wt
206.22
Formula
C8H6N4OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(Nicotinamido)-1,3,4-thiadiazole
References
1. Igarashi H, et al. Neurol Sci. 2011 Feb;32(1):113-6.
2. Huber VJ, et al. Bioorg Med Chem. 2009;17:411–417.
3. Igarashi H, et al. Neuroreport. 2013 Apr 17;24(6):324-8.
