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ARUK2001607

Chemical Structure : ARUK2001607

CAS No.: 2924824-56-4

ARUK2001607 (ARUK 2001607)

Catalog No.: PC-49589Not For Human Use, Lab Use Only.

ARUK2001607 is a potent, selective and brain penetrant PI5P4Kγ inhibitor with binding KD of 7.1 nM, pIC50 of 7.1 (PI5P4Kγ+).

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    Biological Activity

    ARUK2001607 is a potent, selective and brain penetrant PI5P4Kγ inhibitor with binding KD of 7.1 nM, pIC50 of 7.1 (PI5P4Kγ+).
    ARUK2001607 showed excellent selectivity data against >150 kinases and a Cerep safety panel, also showed good potencies at PI5P4Kγ (WT and γ+), were selective vs PI5P4Kα and β.

    Physicochemical Properties

    M.Wt 319.40
    Formula C14H13N3O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-Methyl-N-(4-(methylsulfonyl)phenyl)thieno[2,3-d]pyrimidin-4-amine

    References

    1. Timothy P C Rooney, et al. J Med Chem. 2022 Dec 14. doi: 10.1021/acs.jmedchem.2c01693.

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