Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LMTK3 inhibitor C36
Catalog No.: PC-49503Not For Human Use, Lab Use Only.
LMTK3 inhibitor C36 is a highly selective, ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 100 nM in in vitro kinase assays and MST binding Kd of 1.87 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LMTK3 inhibitor C36 is a highly selective, ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 100 nM in in vitro kinase assays and MST binding Kd of 1.87 uM.
LMTK3 inhibitor C36 has a higher selectivity to purified human kinases when compared to C28 (Catalog#PC-38206).
LMTK3 inhibitor C36 interacts with the ATP-binding site of LMTK3 and with the substrate as well.
LMTK3 inhibitor C36 inhibits the growth of MCF7, T47D, and MDA-MB-231 BC cells, with IC50 values ranging from 16.19 µM to 18.38 µM.
LMTK3 inhibitor C36 (10 uM) inhibited all cancer cell lines by >40% against a panel of 60 human cancer cell lines.
LMTK3 inhibitor C36 (20 uM, 96 h) exhibited an apoptotic effect at 20 μM in MCF7 and T47D BC cell lines, respectively.
| M.Wt | 341.82 | |
| Formula | C16H12ClN5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Alessandro Agnarelli, et al. Int J Mol Sci. 2023 Jan 3;24(1):865.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
