Catalog No.: PC-49503Not For Human Use, Lab Use Only.
LMTK3 inhibitor C36 is a highly selective, ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 100 nM in in vitro kinase assays and MST binding Kd of 1.87 uM.
LMTK3 inhibitor C36 is a highly selective, ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) with IC50 of 100 nM in in vitro kinase assays and MST binding Kd of 1.87 uM.
LMTK3 inhibitor C36 has a higher selectivity to purified human kinases when compared to C28 (Catalog#PC-38206).
LMTK3 inhibitor C36 interacts with the ATP-binding site of LMTK3 and with the substrate as well.
LMTK3 inhibitor C36 inhibits the growth of MCF7, T47D, and MDA-MB-231 BC cells, with IC50 values ranging from 16.19 µM to 18.38 µM.
LMTK3 inhibitor C36 (10 uM) inhibited all cancer cell lines by >40% against a panel of 60 human cancer cell lines.
LMTK3 inhibitor C36 (20 uM, 96 h) exhibited an apoptotic effect at 20 μM in MCF7 and T47D BC cell lines, respectively.
