KL101 | CRY1 stabilizer | Probechem Biochemicals

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Chemical Structure : KL101

KL101 (KL 101)

Catalog No.: PC-49458Not For Human Use, Lab Use Only.

KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1).

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Biological Activity

KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1).
KL101 showed selectivity over CRY2, and no or only minor effects on CKIδ, CKIα and CK2 activities in vitro.

Physicochemical Properties

M.Wt	377.506
Formula	C22H23N3OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2,4-dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethylbenzamide

References

1. Miller S, et al. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2026191118.

2. Miller S, et al. Nat Chem Biol. 2020 Jun;16(6):676-685.

3. Iida M, et al. J Biochem. 2022 May 11;171(5):501-507.

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KL101 (KL 101)

Biological Activity

Physicochemical Properties

References

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