Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-NTE-122
NTE-122

Chemical Structure : NTE-122

CAS No.: 166967-84-6

NTE-122 (NTE122)

Catalog No.: PC-49561Not For Human Use, Lab Use Only.

NTE-122 (NTE122) is a potent selective and competitive acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, inhibits microsomal ACAT activities of various tissues and cultured cells (HepG2 and CaCo-2), with IC50 values from 1.2 to 9.6 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NTE-122 (NTE122) is a potent selective and competitive acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, inhibits microsomal ACAT activities of various tissues and cultured cells (HepG2 and CaCo-2), with IC50 values from 1.2 to 9.6 nM.
    NTE-122 displays no effect on other lipid metabolizing enzymes, such as 3-hydroxy-3-methylglutaryl-CoA reductase, acyl-CoA synthetase, cholesterol esterase, lecithin:cholesterol acyltransferase, acyl-CoA:sn-glycerol-3-phosphate acyltransferase and cholesterol 7alpha-hydroxylase up to 10 uM.
    NTE-122 markedly reduced serum and liver cholesterol levels in the cholesterol diet-fed rats, with ED50 of 0.12 and 0.44 mg/kg/day, respectively.
    NTE-122 significantly lowered plasma and liver cholesterol levels at more than 2 mg/kg/day in the cholesterol diet-fed rabbits.

    Physicochemical Properties

    M.Wt 703.83
    Formula C38H60Cl2N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Urea, N,N′′-[1,4-cyclohexanediylbis(methylene)]bis[N-cyclohexyl-N′-[4-(dimethylamino)phenyl]-, dihydrochloride, trans-

    References

    1. Azuma Y, et al. Jpn J Pharmacol. 1998 Nov;78(3):355-64.

    2. Azuma Y, et al. Jpn J Pharmacol. 1999 Feb;79(2):159-67.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: