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CLOCK inhibitor CLK8

Chemical Structure : CLOCK inhibitor CLK8

CAS No.: 898920-65-5

CLOCK inhibitor CLK8

Catalog No.: PC-49460Not For Human Use, Lab Use Only.

CLOCK inhibitor CLK8 is a CLOCK-binding small molecule disrupting the interaction between CLOCK and BMAL1, interferes with nuclear translocation of CLOCK both in vivo and in vitro.

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    Biological Activity

    CLOCK inhibitor CLK8 is a CLOCK-binding small molecule disrupting the interaction between CLOCK and BMAL1, interferes with nuclear translocation of CLOCK both in vivo and in vitro.
    CLK8 binds in the hollow created between the α2 helix of the bHLH domain and the Hβ strand of the PAS-A domain of CLOCK.
    CLK8 alters CLOCK protein levels in a time-dependent manner in U2OS cells.
    CLK8 (25 mg/kg, i.p.) enhances the amplitude of the circadian rhythm with no change in period length in treated mice.

    Physicochemical Properties

    M.Wt 498.535
    Formula C29H26N2O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(2-((8,8-dimethyl-2-oxo-4-phenyl-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-5-yl)oxy)acetamido)benzamide

    References

    1. Yagmur Umay Doruk, et al. J Biol Chem. 2020 Mar 13;295(11):3518-3531.

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