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2-MPPA

Chemical Structure : 2-MPPA

CAS No.: 254737-29-6

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2-MPPA (GPI-5693)

Catalog No.: PC-21299Not For Human Use, Lab Use Only.

2-MPPA (GPI-5693) is a potent, selective and orally active glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor with IC50 of 90 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    2-MPPA (GPI-5693) is a potent, selective and orally active glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor with IC50 of 90 nM.
    2-MPPA suppresses mossy fiber-CA3 synaptic neurotransmission.
    2-MPPA attenuates morphine tolerance but not dependence in C57/Bl mice.
    2-MPPA is effective in preclinical models of diseases where excess glutamate release is implicated, including neuropathic pain.

    Physicochemical Properties

    M.Wt 206.26
    Formula C8H14O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3-mercaptopropyl) pentanedioic acid

    References

    1. Sanabria ER, et al. J Neurophysiol. 2004 Jan;91(1):182-93.

    2. Kozela E, et al. Psychopharmacology (Berl). 2005 Dec;183(3):275-84.

    3. Vornov JJ, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):406-13.

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