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Chemical Structure : 2-MPPA
Catalog No.: PC-21299Not For Human Use, Lab Use Only.
2-MPPA (GPI-5693) is a potent, selective and orally active glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor with IC50 of 90 nM.
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2-MPPA (GPI-5693) is a potent, selective and orally active glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor with IC50 of 90 nM.
2-MPPA suppresses mossy fiber-CA3 synaptic neurotransmission.
2-MPPA attenuates morphine tolerance but not dependence in C57/Bl mice.
2-MPPA is effective in preclinical models of diseases where excess glutamate release is implicated, including neuropathic pain.
| M.Wt | 206.26 | |
| Formula | C8H14O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sanabria ER, et al. J Neurophysiol. 2004 Jan;91(1):182-93.
2. Kozela E, et al. Psychopharmacology (Berl). 2005 Dec;183(3):275-84.
3. Vornov JJ, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):406-13.
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