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NVS1.1

Chemical Structure : NVS1.1

CAS No.:

NVS1.1 (eRF1 inhibitor)

Catalog No.: PC-21294Not For Human Use, Lab Use Only.

NVS1.1 is a potent readthrough promoter, promotes the rapid and specific degradation of eukaryotic release factor 1 (eRF1) and restores functional full-length proteins in cystic fibrosis and Hurler disease models.

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Biological Activity

NVS1.1 is a potent readthrough promoter, promotes the rapid and specific degradation of eukaryotic release factor 1 (eRF1) and restores functional full-length proteins in cystic fibrosis and Hurler disease models.
NVS1.1 restores α-L-iduronidase (IDUA) enzyme activity and reduces the GAG levels in a dose-dependent manner in human patient-derived fibroblasts.
NVS1.1 stimulates premature termination codon (PTC) suppression by triggering rapid proteasomal degradation of the translation termination factor eRF1.
NVS1.1 blocks translation termination by trapping eRF1 in the A site, causing ribosome collisions.
NVS1.1 is efficacious in a rat Hurler IDUA-W401X animal model, shows good drug-like properties with favorable pharmacokinetics, metabolic stability, and suitability for oral administration.

Physicochemical Properties

M.Wt 361.84
Formula C17H16ClN3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-(2-chloro-5-(methylsulfonyl)-4-(1H-pyrazol-5-yl)phenyl)(phenyl)methanamine

References

1. Gurzeler LA, et al. Cell Rep. 2023 Sep 26;42(9):113056.

2. Patent WO2014/091446A1

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