YL-365 | GPR34 inhibitor | Probechem Biochemicals

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Chemical Structure : YL-365

YL-365 (YL365)

Catalog No.: PC-21213Not For Human Use, Lab Use Only.

YL-365 (YL365) is a highly potent, selective and competitive antagonist of GPR34.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YL-365 (YL365) is a highly potent, selective and competitive antagonist of GPR34.
YL-365 binds to a portion of the orthosteric binding pocket of GPR34 and the antagonist-binding-induced allostery in the receptor, implicating the inhibition mechanism.
YL-365 displays excellent activity in a neuropathic pain model without obvious toxicity.

Physicochemical Properties

M.Wt	583.08
Formula	C34H31ClN2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-(benzyloxy)phenyl)acetamido)-1-(3'-chloro-[1,1'-biphenyl]-4-carbonyl)piperidine-4-carboxylic acid

References

1. Anjie Xia, et al. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2308435120.

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YL-365 (YL365)

Biological Activity

Physicochemical Properties

References

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