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Chemical Structure : YL-365
Catalog No.: PC-21213Not For Human Use, Lab Use Only.
YL-365 (YL365) is a highly potent, selective and competitive antagonist of GPR34.
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YL-365 (YL365) is a highly potent, selective and competitive antagonist of GPR34.
YL-365 binds to a portion of the orthosteric binding pocket of GPR34 and the antagonist-binding-induced allostery in the receptor, implicating the inhibition mechanism.
YL-365 displays excellent activity in a neuropathic pain model without obvious toxicity.
| M.Wt | 583.08 | |
| Formula | C34H31ClN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Anjie Xia, et al. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2308435120.
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