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Feeblin

Chemical Structure : Feeblin

CAS No.: 689270-18-6

Feeblin (SLC15A4 inhibitor C5)

Catalog No.: PC-21265Not For Human Use, Lab Use Only.

Feeblin (SLC15A4 inhibitor C5) is a small molecule inhibitor of the proinflammatory TLR7/8/9-IRF5 pathway (IC50=1.6 uM) by disrupting the SLC15A4-TASL adapter module, Feeblin is an IRF5 pathway-specific inhibitor.

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    Biological Activity

    Feeblin (SLC15A4 inhibitor C5) is a small molecule inhibitor of the proinflammatory TLR7/8/9-IRF5 pathway (IC50=1.6 uM) by disrupting the SLC15A4-TASL adapter module, Feeblin is an IRF5 pathway-specific inhibitor.
    Feeblin (SLC15A4 inhibitor C5) displays specific inhibition of IRF5, shows no or little activity on STING, NOD1/2 or RIG-like helicase pathways.
    Feeblin (SLC15A4 inhibitor C5) significantly reduces IRF5 nuclear translocation, without affecting the activation of NF-κB p65.
    Feeblin (SLC15A4 inhibitor C5) locks SLC15A4 in a TASL binding-incompetent lysosomal outward-open conformation.

    Physicochemical Properties

    M.Wt 431.58
    Formula C27H33N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(4-ethoxyphenyl)-N-(3-(2-methylpiperidin-1-yl)propyl)quinoline-4-carboxamide

    References

    1. Andras Boeszoermenyi, et al. Nat Commun. 2023 Oct 20;14(1):6626.

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