Chemical Structure : MBLAC2 inhibitor KV-79
Catalog No.: PC-24577Not For Human Use, Lab Use Only.
MBLAC2 inhibitor KV-79 is a potent, specific inhibitor of the metalloenzyme MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) with EC50 of 24 nM, >60 fold selectivity over HDAC6.
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MBLAC2 inhibitor KV-79 is a potent, specific inhibitor of the metalloenzyme MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) with EC50 of 24 nM, >60 fold selectivity over HDAC6.
KV-79 does not affect cell proliferation or fitness at concentrations up to 10 μM, but upregulates extracellular vesicles (EVs) in HEK293 cells.
KV-79 is a valuable tool for elucidating the cell biological functions of MBLAC2.
M.Wt | 416.42 | |
Formula | C21H15F3N2O2S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Severin Lechner, et al. ACS Chem Biol. 2025 May 8. doi: 10.1021/acschembio.5c00108.
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