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LX2931

Chemical Structure : LX2931

CAS No.: 948840-25-3

LX2931 (LX-2931)

Catalog No.: PC-60694Not For Human Use, Lab Use Only.

LX-2931 (LX2931) is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LX2931 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor.
LX2931 dose-dependently decreases circulating lymphocyte numbers in multiple species and shows a therapeutic effect in rodent models of rheumatoid arthritis (RA).
LX2931 also increases S1P levels in F508del CFTR mutant mice, reduces MUC5AC and proinflammatory cytokine levels toward normal values.

Physicochemical Properties

M.Wt 245.235
Formula C9H15N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime

References

1. Bagdanoff JT, et al. J Med Chem. 2010 Dec 23;53(24):8650-62.

2. Veltman M, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L1000-L1014.

3. Finney CA, et al. Mol Med. 2011;17(7-8):717-25.

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