Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ADDA 5
CAS No.: 473268-46-1
Catalog No.: PC-60849Not For Human Use, Lab Use Only.
ADDA 5 is a specific, non-competitive, small molecule cytochrome c oxidase (CcO or complex IV) inhibitor with IC50 of 18.93 uM (CcO from human glioma).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ADDA 5 is a specific, non-competitive, small molecule cytochrome c oxidase (CcO or complex IV) inhibitor with IC50 of 18.93 uM (CcO from human glioma).
ADDA 5 displays no inhibition of other mitochondrial complexes or other relevant enzymes (LDH, XO, SOD, GPs etc.).
ADDA 5 dose-dependently inhibited the proliferation of chemosensitive and chemoresistant glioma cells but does not display toxicity against non-cancer cells.
ADDA 5 also blcoks cell proliferation and neurosphere formation in cultures of glioma stem cells, inhibits tumor growth in flank xenograft mouse models.
| M.Wt | 406.007 | |
| Formula | C24H36ClNO2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-[2-(1-adamantyl)ethoxy]-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-propanol hydrochloride |
|
1. Oliva CR, et al. J Biol Chem. 2016 Nov 11;291(46):24188-24199.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
