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Chemical Structure : S1P Lyase inhibitor 31
Catalog No.: PC-60693Not For Human Use, Lab Use Only.
S1P Lyase inhibitor 31 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM.
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S1P Lyase inhibitor 31 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM.
S1P Lyase inhibitor 31 displays acceptable selectivity in a panel of 74 receptors and enzymes at 10 uM.
S1P Lyase inhibitor 31 induces profound reduction of peripheral T cell numbers after oral dosage and confers pronounced protection in a rat model of multiple sclerosis.
| M.Wt | 454.962 | |
| Formula | C26H23ClN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Harris CM, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):151-8.
2. Weiler S, et al. J Med Chem. 2014 Jun 26;57(12):5074-84.
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