Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-S1P Lyase inhibitor 31
S1P Lyase inhibitor 31

Chemical Structure : S1P Lyase inhibitor 31

CAS No.: 1538574-95-6

S1P Lyase inhibitor 31 (S1PL inhibitor 31)

Catalog No.: PC-60693Not For Human Use, Lab Use Only.

S1P Lyase inhibitor 31 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM.

Packing Price Stock Quantity
25 mg Get quote
100 mg Get quote
250 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

S1P Lyase inhibitor 31 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM.
S1P Lyase inhibitor 31 displays acceptable selectivity in a panel of 74 receptors and enzymes at 10 uM.
S1P Lyase inhibitor 31 induces profound reduction of peripheral T cell numbers after oral dosage and confers pronounced protection in a rat model of multiple sclerosis.

Physicochemical Properties

M.Wt 454.962
Formula C26H23ClN6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile

References

1. Harris CM, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):151-8.

2. Weiler S, et al. J Med Chem. 2014 Jun 26;57(12):5074-84.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: