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S1P Lyase inhibitor 31

Chemical Structure : S1P Lyase inhibitor 31

CAS No.: 1538574-95-6

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S1P Lyase inhibitor 31 (S1PL inhibitor 31)

Catalog No.: PC-60693Not For Human Use, Lab Use Only.

S1P Lyase inhibitor 31 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

S1P Lyase inhibitor 31 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM.
S1P Lyase inhibitor 31 displays acceptable selectivity in a panel of 74 receptors and enzymes at 10 uM.
S1P Lyase inhibitor 31 induces profound reduction of peripheral T cell numbers after oral dosage and confers pronounced protection in a rat model of multiple sclerosis.

Physicochemical Properties

M.Wt 454.962
Formula C26H23ClN6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile

References

1. Harris CM, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):151-8.

2. Weiler S, et al. J Med Chem. 2014 Jun 26;57(12):5074-84.

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