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TK05

Chemical Structure : TK05

CAS No.: 1245734-61-5

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TK05 (TK 05, TK-05)

Catalog No.: PC-60717Not For Human Use, Lab Use Only.

TK05 is a potent and selective inhibitors of leukotriene C4 synthase (LTC4S) with IC50 of 95 nM, Ki of 6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TK05 is a potent and selective inhibitors of leukotriene C4 synthase (LTC4S) with IC50 of 95 nM, Ki of 6 nM.
    TK05 shows no significant inhibitory effect on mPGES-1, MGST2, or 5-LO at 10 uM.
    TK05 potently inhibits cys-LT biosynthesis in immune cells (MM6 cell) with IC50 of 318 nM, increases lipoxin A4 levels in platelets and polymorphonuclear leukocytes.
    TK05 reduces LTE4 levels in peritoneal lavage fluid and significantly decreases vascular permeability in vivo.

    Physicochemical Properties

    M.Wt 541
    Formula C31H25ClN2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)picolinoyl)-2-(4-methoxybenzoyl)benzoic acid

    References

    1. Kleinschmidt TK, et al. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16.

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