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Chemical Structure : NGI-1
CAS No.: 790702-57-7
Catalog No.: PC-60959Not For Human Use, Lab Use Only.
NGI-1 (ML414) is a potent, cell-permeable oligosaccharyltransferase (OST) inhibitor with IC50 of 1.1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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NGI-1 (ML414) is a potent, cell-permeable oligosaccharyltransferase (OST) inhibitor with IC50 of 1.1 uM.
NGI-1 (ML414) blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein in NSCLC cells.
NGI-1 (ML414) causes cell-cycle arrest accompanied by induction of p21, autofluorescence, and cell morphology changes, all hallmarks of senescence.
NGI-1 (ML414) reduces the production of both OST products (free glycans and N-glycans).
NGI-1 (ML414) is a small molecule chemical probe with N-linked glycosylation inhibitory activity.
| M.Wt | 394.508 | |
| Formula | C17H22N4O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-(N,N-dimethylsulfamoyl)-N-(5-methylthiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide |
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1. Puschnik AS, et al. Cell Rep. 2017 Dec 12;21(11):3032-3039.
2. Lopez-Sambrooks C, et al. Nat Chem Biol. 2016 Dec;12(12):1023-1030.
3. Baro M, et al. Clin Cancer Res. 2018 Jul 2. pii: clincanres.0792.2018. doi: 10.1158/1078-0432.CCR-18-0792.
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