Fumonisin B1 | Ceramide synthase inhibitor

Chemical Structure : Fumonisin B1

CAS No.: 116355-83-0

Fumonisin B1 (FB1)

Catalog No.: PC-61424Not For Human Use, Lab Use Only.

Fumonisin B1 is a mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS).

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5 mg	$458	In stock
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Biological Activity

Fumonisin B1 is a mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS).
Fumonisin B1 attenuates the response of P388D1 cells to PAF and LPS by inhibiting ceramide formation.
Fumonisin B1 blocks the apoptotic response of HaCaT cells to the antiproliferative drug hexadecylphosphocholine, through inhibition of ceramide production.
Fumonisin B1 alteres cell morphology and decreases in cell proliferation in Swiss 3T3 cells.

Physicochemical Properties

M.Wt	721.8
Formula	C34H59NO15
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,2’R)-1,2,3-propanetricarboxylic acid, 1,1’-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] ester

References

1. Merrill AH Jr, et al. J Biol Chem. 1993 Dec 25;268(36):27299-306.

2. Balsinde J, et al. J Biol Chem. 1997 Aug 15;272(33):20373-7.

3. Meivar-Levy I, et al. J Biol Chem. 1999 Feb 19;274(8):4607-12.

Fumonisin B1 (FB1)

Biological Activity

Physicochemical Properties

References

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