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Chemical Structure : Fumonisin B1
CAS No.: 116355-83-0
Catalog No.: PC-61424Not For Human Use, Lab Use Only.
Fumonisin B1 is a mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS).
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Fumonisin B1 is a mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS).
Fumonisin B1 attenuates the response of P388D1 cells to PAF and LPS by inhibiting ceramide formation.
Fumonisin B1 blocks the apoptotic response of HaCaT cells to the antiproliferative drug hexadecylphosphocholine, through inhibition of ceramide production.
Fumonisin B1 alteres cell morphology and decreases in cell proliferation in Swiss 3T3 cells.
| M.Wt | 721.8 | |
| Formula | C34H59NO15 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,2’R)-1,2,3-propanetricarboxylic acid, 1,1’-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] ester |
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1. Merrill AH Jr, et al. J Biol Chem. 1993 Dec 25;268(36):27299-306.
2. Balsinde J, et al. J Biol Chem. 1997 Aug 15;272(33):20373-7.
3. Meivar-Levy I, et al. J Biol Chem. 1999 Feb 19;274(8):4607-12.
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