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Lucerastat

Chemical Structure : Lucerastat

CAS No.: 141206-42-0

Lucerastat (NB-DGJ, N-Butyldeoxygalactonojirimycin, ACT-434964, OGT-923)

Catalog No.: PC-61429Not For Human Use, Lab Use Only.

Lucerastat (NB-DGJ, ACT-434964) is a galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM).

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Biological Activity

Lucerastat (NB-DGJ, ACT-434964) is a galactose analogue that is an UDP-glucose ceramide glucosyltransferase (UGCG/GCS) inhibitor (IC50=41.4 uM).
Lucerastat prevents glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders, without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50>1 mM).
Lucerastat shows potential as substrate reduction therapy for glycolipid storage disorders such as Gaucher disease and Fabry disease.

Physicochemical Properties

M.Wt 219.281
Formula C10H21NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

References

1. Platt FM, et al. J Biol Chem. 1994 Oct 28;269(43):27108-14.

2. Andersson U, et al. Biochem Pharmacol. 2000 Apr 1;59(7):821-9.

3. Kasperzyk JL, et al. J Neurochem. 2004 May;89(3):645-53.

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