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Myriocin

Chemical Structure : Myriocin

CAS No.: 35891-70-4

Myriocin (ISP-1, Thermozymocidin)

Catalog No.: PC-61423Not For Human Use, Lab Use Only.

Myriocin (ISP-1) is an amino fatty acid antibiotic that is 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo.

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Biological Activity

Myriocin (ISP-1) is an amino fatty acid antibiotic that is 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo.
Myriocin (ISP-1) is a potent inhibitor of serine palmitoyltransferase (SPT) with Ki of 0.28 nM.
Myriocin (ISP-1) inhibits the proliferation of IL-2-dependent mouse cytotoxic T cell line CTLL-2 (IC50=15 nM) by the modulation of sphingolipid metabolism.

Physicochemical Properties

M.Wt 401.5
Formula C21H39NO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid

References

1. Fujita T, et al. J Antibiot (Tokyo). 1994 Feb;47(2):208-15.

2. Miyake Y, et al. Biochem Biophys Res Commun. 1995 Jun 15;211(2):396-403.

3. Nakamura S, et al. J Biol Chem. 1996 Jan 19;271(3):1255-7.

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