Enexasogaol (6-Shogaol) is a pungent agent isolated from Zingiber officinale Roscoe, has been known to have anti-tumor and anti-inflammatory effects.
Enexasogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ.
Enexasogaol inhibits TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.
Enexasogaol also induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism.
Physicochemical Properties
M.Wt
276.376
Formula
C17H24O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(4E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one
References
1. Isa Y, et al. Biochem Biophys Res Commun. 2008 Aug 29;373(3):429-34.
2. Pan MH, et al. Mol Nutr Food Res. 2008 May;52(5):527-37.
3. Chen CY, et al. J Agric Food Chem. 2007 Feb 7;55(3):948-54.
4. Han Q,et al. Oncotarget. 2017 Jun 27;8(26):42001-42006.
