Epeleuton |CAS:1667760-39-5 Probechem Biochemicals

Chemical Structure : Epeleuton

Epeleuton (15 hydroxy eicosapentaenoic acid ethyl ester)

Catalog No.: PC-61376Not For Human Use, Lab Use Only.

Epeleuton is an orally administered, second-generation ω-3 fatty acid derivative of C20:5 n-3 EPA, protects against cellular stress associated with SCD and supports early initiation of the resolution phase of inflammation.

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Biological Activity

Epeleuton has protective effects against inflammatory vasculopathy and markers of systemic inflammation, suggesting its possible transferability to SCD.

Epeleuton significantly increased organ concentrations of 15-HEPE, which has both anti-inflammatory and pro-resolving functions.

Epeleuton reduces circulating neutrophils and promotes a pro-resolving lipidomic profile in lung and liver of mice with sickle cell disease.

Epeleuton promotes a pro-resolving profile in target organs and prevents the activation of the NF-kB pathway in mice with sickle cell disease.

Physicochemical Properties

M.Wt	346.511
Formula	C22H34O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl (5Z,8Z,11Z,13E,15S,17Z)-15-hydroxyicosa-5,8,11,13,17-pentaenoate

References

1. Mattè A, et al. Haematologica. 2024 Jun 1;109(6):1918-1932.

Epeleuton (15 hydroxy eicosapentaenoic acid ethyl ester)

Biological Activity

Physicochemical Properties

References

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