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Epeleuton

Chemical Structure : Epeleuton

CAS No.: 1667760-39-5

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Epeleuton (15 hydroxy eicosapentaenoic acid ethyl ester)

Catalog No.: PC-61376Not For Human Use, Lab Use Only.

Epeleuton is an orally administered, second-generation ω-3 fatty acid derivative of C20:5 n-3 EPA, protects against cellular stress associated with SCD and supports early initiation of the resolution phase of inflammation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Epeleuton is an orally administered, second-generation ω-3 fatty acid derivative of C20:5 n-3 EPA, protects against cellular stress associated with SCD and supports early initiation of the resolution phase of inflammation.
    Epeleuton has protective effects against inflammatory vasculopathy and markers of systemic inflammation, suggesting its possible transferability to SCD.
    Epeleuton significantly increased organ concentrations of 15-HEPE, which has both anti-inflammatory and pro-resolving functions.
    Epeleuton reduces circulating neutrophils and promotes a pro-resolving lipidomic profile in lung and liver of mice with sickle cell disease.
    Epeleuton promotes a pro-resolving profile in target organs and prevents the activation of the NF-kB pathway in mice with sickle cell disease.

    Physicochemical Properties

    M.Wt 346.511
    Formula C22H34O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Ethyl (5Z,8Z,11Z,13E,15S,17Z)-15-hydroxyicosa-5,8,11,13,17-pentaenoate

    References

    1. Mattè A, et al. Haematologica. 2024 Jun 1;109(6):1918-1932.

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