Chemical Structure : DC_AC50
CAS No.:
497061-48-0
DC_AC50
(DC-AC50;DC AC50;DCAC50)
Catalog No.: PC-61245Not For Human Use, Lab Use Only.
DC_AC50 (DCAC50) is a small molecule that inhibits the human copper chaperones Atox1 and CCS (Kd=6.8 and 8.2 uM), blocks copper trafficking and significantly attenuates cancer cell proliferation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DC_AC50 (DCAC50) is a small molecule that inhibits the human copper chaperones Atox1 and CCS (Kd=6.8 and 8.2 uM), blocks copper trafficking and significantly attenuates cancer cell proliferation; induces cellular reactive oxygen species (ROS) accumulation and reduces cellular ATP production, induces mitochondria defects and decreases lipid biosynthesis through AMPK activation; suppresses tumour growth effectively without affecting normal tissues in mice.
Physicochemical Properties
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M.Wt
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424.264
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Formula
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C17H12BrF2N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide
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References
1. Wang J, et al. Nat Chem. 2015 Dec;7(12):968-79.
2. Karginova O, et al. Mol Cancer Ther. 2019 Mar 1. pii: molcanther.0667.2018.
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