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DC_AC50

Chemical Structure : DC_AC50

CAS No.: 497061-48-0

DC_AC50 (DC-AC50;DC AC50;DCAC50)

Catalog No.: PC-61245Not For Human Use, Lab Use Only.

DC_AC50 (DCAC50) is a small molecule that inhibits the human copper chaperones Atox1 and CCS (Kd=6.8 and 8.2 uM), blocks copper trafficking and significantly attenuates cancer cell proliferation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DC_AC50 (DCAC50) is a small molecule that inhibits the human copper chaperones Atox1 and CCS (Kd=6.8 and 8.2 uM), blocks copper trafficking and significantly attenuates cancer cell proliferation; induces cellular reactive oxygen species (ROS) accumulation and reduces cellular ATP production, induces mitochondria defects and decreases lipid biosynthesis through AMPK activation; suppresses tumour growth effectively without affecting normal tissues in mice.

Physicochemical Properties

M.Wt 424.264
Formula C17H12BrF2N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide

References

1. Wang J, et al. Nat Chem. 2015 Dec;7(12):968-79.

2. Karginova O, et al. Mol Cancer Ther. 2019 Mar 1. pii: molcanther.0667.2018.

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