Catalog No.: PC-61320Not For Human Use, Lab Use Only.
RK-33 is a first-in-class small molecule inhibitor of RNA helicase DDX3, binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17.
RK-33 is a first-in-class small molecule inhibitor of RNA helicase DDX3, binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17.
RK-33 causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
RK-33 exhibits growth inhibitory properties against NCI-60 panel of cell lines with GI50 of <1 uM-7 uM.
RK-33 inhibits Wnt signaling mediated by DDX3, and promotes tumor regression in preclinical models of DDX3-overexpressing lung cancer in combination with radiation.
