Spindlactone B (SPL-B)

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Chemical Structure : Spindlactone B

Catalog No.: PC-61361Not For Human Use, Lab Use Only.

Spindlactone B (SPL-B) is a novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Spindlactone B (SPL-B) is a novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells.
Spindlactone Bbinds to and inhibits the function of the TACC3-TOGp complex, induces aberrant spindles and mitotic arrest in ovarian cancer cells.
Spindlactone B significantly suppresses tumor growth in vivo and exhibits excellent oral bioavailability.

Physicochemical Properties

M.Wt	454.482
Formula	C27H22N2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8'-[[Ethyl(4-pyridinylmethyl)amino]methyl]-7'-hydroxy[3,4'-bi-2H-1-benzopyran]-2,2'-dione

References

1. Yao R, et al. Oncogene. 2014 Aug 14;33(33):4242-52.

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