Spindlactone A (SPL-A)

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Chemical Structure : Spindlactone A

Catalog No.: PC-61360Not For Human Use, Lab Use Only.

Spindlactone A (SPL-A) is a novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Spindlactone A (SPL-A) is a novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells.
Spindlactone A binds to and inhibits the function of the TACC3-TOGp complex, induces aberrant spindles in SKOV-3 cells, with no affect for spindle assembly in normal cells.
Spindlactone A selectively induces mitotic arrest in ovarian cancer cells.

Physicochemical Properties

M.Wt	447.487
Formula	C26H25NO6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7'-hydroxy-8'-((4-(2-hydroxyethyl)piperidin-1-yl)methyl)-2H,2'H-[3,4'-bichromene]-2,2'-dione

References

1. Yao R, et al. Oncogene. 2014 Aug 14;33(33):4242-52.

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