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Chemical Structure : Spindlactone A
Catalog No.: PC-61360Not For Human Use, Lab Use Only.
Spindlactone A (SPL-A) is a novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells.
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Spindlactone A (SPL-A) is a novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells.
Spindlactone A binds to and inhibits the function of the TACC3-TOGp complex, induces aberrant spindles in SKOV-3 cells, with no affect for spindle assembly in normal cells.
Spindlactone A selectively induces mitotic arrest in ovarian cancer cells.
| M.Wt | 447.487 | |
| Formula | C26H25NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yao R, et al. Oncogene. 2014 Aug 14;33(33):4242-52.
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