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Chemical Structure : Teglicar
Catalog No.: PC-61316Not For Human Use, Lab Use Only.
Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.
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Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.
Teglicar displays an extraordinarily high selectivity (39-fold) toward the liver isoform over the heart isoform (muscle-CPT1;M-CPT1).
Teglicar reduces gluconeogenesis and improves glucose homeostasis, shows antiketotic and antidiabetic activity in diabetic db/db mice.
Teglicar also inhibits fatty acid oxidation associated with cell growth arrest, mitochondrial damage, and apoptosis induction in leukemia cell lines.
Teglicar is orally active.
| M.Wt | 399.62 | |
| Formula | C22H45N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ricciardi MR, et al. Blood. 2015 Oct 15;126(16):1925-9.
2. Giannessi F, et al. J Med Chem. 2003 Jan 16;46(2):303-9.
3. Conti R, et al. Diabetes. 2011 Feb;60(2):644-51.
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