Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : UNC-3230
CAS No.: 1031602-63-7
Catalog No.: PC-61242Not For Human Use, Lab Use Only.
UNC-3230 (UNC3230) is a selective, small molecule inhibitor of PIP5K1C with IC50 of 41 nM, does not ihibits other lipid kinases including PI3Ks.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
UNC-3230 (UNC3230) is a selective, small molecule inhibitor of PIP5K1C with IC50 of 41 nM, does not ihibits other lipid kinases including PI3Ks.
UNC-3230 shows selectivity (Kd<0.2 uM) for PIP5K1C and PIP4K2C.
UNC-3230 significantly reduces membrane PIP2 levels by ~45% in DRG neurons at 100 nM, also reduces LPA-evoked calcium signaling.
UNC-3230 demonstrates antinociceptive effects, reduces thermal and mechanical sensitization in models of chronic pain.
| M.Wt | 344.43 | |
| Formula | C17H20N4O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5- (cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide |
|
1. Wright BD, et al. Neuron. 2014 May 21;82(4):836-47.
2. Wright BD, et al. J Biomol Screen. 2015 Jun;20(5):655-62.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
