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RP-54745

Chemical Structure : RP-54745

CAS No.: 135330-08-4

RP-54745 (RP 54745, RP54745 )

Catalog No.: PC-24063Not For Human Use, Lab Use Only.

RP-54745 is a potential antirheumatic compound and interleukin-1 (IL-1) inhibitor, inhibits LPS-induced IL-1 production by murine peritoneal macrophages.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RP-54745 is a potential antirheumatic compound and interleukin-1 (IL-1) inhibitor, inhibits LPS-induced IL-1 production by murine peritoneal macrophages.
RP-54745 effectively repressed KSHV + PEL cell growth through inducing tumor cell apoptosis.
RP-54745 significantly reduced hyperinflammation in tumor microenvironment including myeloid cells and neutrophils infiltration, as well as blocking IL-1 signaling molecules expression in primary effusion lymphoma (PEL) xenograft model.

Physicochemical Properties

M.Wt 297.82
Formula C13H12ClNOS2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Chloro-5-(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-3H-1,2-dithiol-3-one

References

1. Folliard F, et al. Agents Actions. 1992 May;36(1-2):119-26.

2. Dai L, et al. J Med Virol. 2025 Feb;97(2):e70200.

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