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dMGer

Chemical Structure : dMGer

CAS No.: 2975602-21-0

dMGer (DesmethylGerminone, dMgerminone)

Catalog No.: PC-24060Not For Human Use, Lab Use Only.

dMGer (DesmethylGerminone) is a potent and selective HTL/KAI2 (KAI2) agonist, inhibits KAI2-dependent dMYLG hydrolysis with IC50 of 46 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

dMGer (DesmethylGerminone) is a potent and selective HTL/KAI2 (KAI2) agonist, inhibits KAI2-dependent dMYLG hydrolysis with IC50 of 46 nM.
dMGer is a more specific KAI2 agonist than Germinone (Ger).
dMGer clearly lowered the melting temperature of KAI2 in DSF assays, but not Ger.
dMGer specifically induces the interaction between KAI2 and SMAX1.
dMGer retains the ability to simply bind to DWARF14 (D14).
dMGer is a potent seed germination stimulant that functions as a chemical agonist of the KAI2 receptor and bypasses the GA-dependent pathway.

Physicochemical Properties

M.Wt 297.27
Formula C16H11NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((3-nitro-[1,1'-biphenyl]-4-yl)oxy)furan-2(5H)-one

References

1. Okabe S, et al. Biochem Biophys Res Commun. 2023 Mar 15;649:110-117.

2. Kushihara R, et al. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2414779122.

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