Catalog No.: PC-21054Not For Human Use, Lab Use Only.
SOFTI is a small molecule inhibitor of O-fucosyltransferase SPINDLY (SPY) with IC50 of 13.32 uM, binds to the GDP-fucose-binding pocket of SPY and competitively inhibits GDP-fucose binding.
SOFTI is a small molecule inhibitor of O-fucosyltransferase SPINDLY (SPY) with IC50 of 13.32 uM, binds to the GDP-fucose-binding pocket of SPY and competitively inhibits GDP-fucose binding.
SPY O-fucosyltransferase inhibitor (SOFTI) is a specific small molecule inhibitor of SPINDLY O-fucosyltransferase with KD of 37 uM in BLI assays.
SOFTI displays concentration-dependent inhibition of the self-fucosylation of recombinant 3TPR-SPY proteins with IC50 of 13.32 uM.
SOFTI has little effect on the O-fucosyltransferases in the endoplasmic reticulum.
