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SOFTI

Chemical Structure : SOFTI

CAS No.: 1200133-34-1

SOFTI (SPINDLY O-fucosyltransferase inhibitor, SPI-1)

Catalog No.: PC-21054Not For Human Use, Lab Use Only.

SOFTI is a small molecule inhibitor of O-fucosyltransferase SPINDLY (SPY) with IC50 of 13.32 uM, binds to the GDP-fucose-binding pocket of SPY and competitively inhibits GDP-fucose binding.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SOFTI is a small molecule inhibitor of O-fucosyltransferase SPINDLY (SPY) with IC50 of 13.32 uM, binds to the GDP-fucose-binding pocket of SPY and competitively inhibits GDP-fucose binding.
SPY O-fucosyltransferase inhibitor (SOFTI) is a specific small molecule inhibitor of SPINDLY O-fucosyltransferase with KD of 37 uM in BLI assays.
SOFTI displays concentration-dependent inhibition of the self-fucosylation of recombinant 3TPR-SPY proteins with IC50 of 13.32 uM.
SOFTI has little effect on the O-fucosyltransferases in the endoplasmic reticulum.

Physicochemical Properties

M.Wt 497.74
Formula C26H36KNO4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(cyclohex-1-en-1-yl)-3-((1r,4R)-N-((1r,4R)-4-methoxycyclohexyl)-4-methylcyclohexane-1-carboxamido)thiophene-2-carboxylic acid

References

1. Aizezi Y, et al. Plant Cell. 2023 Dec 20:koad299.

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