Catalog No.: PC-21002Not For Human Use, Lab Use Only.
FDW028 is a potent and highly selective small-molecule inhibitor of fucosyltransferase 8 (FUT8) with binding KD value of 5.486 uM, displays no affinity against other FUTs, shows potent anti-CRC activities.
FDW028 is a potent and highly selective small-molecule inhibitor of fucosyltransferase 8 (FUT8) with binding KD value of 5.486 uM, displays no affinity against other FUTs, shows potent anti-CRC activities.
FDW028 exerts potent anti-tumor activities against CRC with IC50 of 5.95 µM and 23.78 µM in SW480 and HCT-8 cells, respectively, significantly represses the migration of SW480 and HCT-8 cells.
FDW028 promotes defucosylation and consequent CMA lysosomal degradation of B7-H3 through CMA pathway.
FDW028 apparently attenuates the expression of both PD-L1 and PD-L2 in CRC cells.
FDW028 attenuates membrane B7-H3 through driving the binding of HSC70 to B7-H3 and consequent autophagolysosomal degradation of B7-H3.
FDW028 (20 mg/kg once the other day, i.v.) prolongs the survival of mice with CRC pulmonary metastases (CRPM).
