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BDP-13176

Chemical Structure : BDP-13176

CAS No.: 2290660-61-4

BDP-13176 (BDP 13176, BDP13176)

Catalog No.: PC-21071Not For Human Use, Lab Use Only.

BDP-13176 is a small molecule inhibitor of actin-bundling protein Fascin-1 (Fscn1) with SPR and ITC Kd values of 85 and 50 nM, respectively, inhibits fascin-mediated actin bundling with IC50 of 240 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BDP-13176 is a small molecule inhibitor of actin-bundling protein Fascin-1 (Fscn1) with SPR and ITC Kd values of 85 and 50 nM, respectively, inhibits fascin-mediated actin bundling with IC50 of 240 nM.
BDP-13176 is a useful chemical probe for fascin's potential role in tumor invasion and metastasis.

Physicochemical Properties

M.Wt 497.38
Formula C24H22Cl2N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Pyrazolo[4,3-c]pyridine-7-carboxamide, 5-[(3,4-dichlorophenyl)methyl]-4,5-dihydro-4-oxo-1-(4-piperidinyl)-N-4-pyridinyl-

References

1. Stuart Francis, et al. Bioorg Med Chem Lett. 2019 Apr 15;29(8):1023-1029.

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