Catalog No.: PC-21021Not For Human Use, Lab Use Only.
PF-07208254 (PF 07208254) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK, BCKDK) inhibitor with in vitro IC50 of 110 nM and Ki of 54 nM.
PF-07208254 (PF 07208254) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK, BCKDK) inhibitor with in vitro IC50 of 110 nM and Ki of 54 nM.
PF-07208254 exhibits potent inhibitory potency in human skeletal myocytes using an AlphaLISA SureFire Ultra detection system to monitor BCKDH phosphorylation (cellular IC50 = 540 nM).
PF-07208254 exhibits Kd value of 84 nM in surface plasmon resonance (SPR)-based binding assays.
PF-07208254 demonstrates superior potency relative to BT2 (Cat. PC-49378, IC50=1100 nM in vitro).
PF-07208254 (90 mg/kg) improves cardiac function and metabolism, reduces pBCKDH in mice.
PF-07208254 reduces pBCKDH and promotes BDK protein levels in human cells and in mice.
