You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-NP-G2-044
NP-G2-044

Chemical Structure : NP-G2-044

CAS No.: 1807454-59-6

NP-G2-044 (Fascin inhibitor)

Catalog No.: PC-21070Not For Human Use, Lab Use Only.

NP‐G2‐044 is a small molecule inhibitor of actin-bundling protein Fascin-1 (Fscn1), inhibits fascin-mediated actin bundling with IC50 of 0.2 uM.

Packing Price Stock Quantity
5 mg $98 In stock
10 mg $148 In stock
25 mg $268 In stock
50 mg $428 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NP‐G2‐044 is a small molecule inhibitor of actin-bundling protein Fascin-1 (Fscn1), inhibits fascin-mediated actin bundling with IC50 of 0.2 uM.
Fascin (E391A mutant) (from the actin‐binding site 1) is insensitive to the inhibition by NP‐G2‐044.
NP‐G2‐044 engages the target fascin and blocks filopodial formation in cells, decreases filopodial formation resulting in decreased lamellipodial formation.
NP‐G2‐044 inhibits the migration of MDA‐MB‐231 tumor cells with IC50 of ~10 uM.
NP‐G2‐044 (intraperitoneally and daily at 100 mg/kg) inhibits tumor metastasis on breast tumor metastasis in mouse models.

Physicochemical Properties

M.Wt 399.37
Formula C21H16F3N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Methyl-N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)furan-3-carboxamide

References

1. Shaoqin Han, et al. Mol Oncol. 2016 Aug;10(7):966-80.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: