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Chemical Structure : PF-07247685
Catalog No.: PC-21020Not For Human Use, Lab Use Only.
PF-07247685 (PF-07247685) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with in vitro IC50 of 0.86 nM, and SPR Kd of 0.68 nM.
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PF-07247685 (PF-07247685) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with in vitro IC50 of 0.86 nM, and SPR Kd of 0.68 nM.
PF-07247685 exhibits potent inhibitory potency in human skeletal myocytes using an AlphaLISA SureFire Ultra detection system to monitor BCKDH phosphorylation (cellular IC50 =3.0 nM).
PF-07247685 demonstrates superior potency relative to BT2 (Cat. PC-49378, IC50=1100 nM in vitro).
PF-07247685 acutely lowers tissue BCAA/BCKA in HFD-fed mouse tissues, increases BDK protein levels.
| M.Wt | 380.46 | |
| Formula | C21H20N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rachel J Roth Flach, et al. Nat Commun. 2023 Aug 9;14(1):4812.
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