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PF-07247685

Chemical Structure : PF-07247685

CAS No.:

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PF-07247685 (PF 07247685)

Catalog No.: PC-21020Not For Human Use, Lab Use Only.

PF-07247685 (PF-07247685) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with in vitro IC50 of 0.86 nM, and SPR Kd of 0.68 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-07247685 (PF-07247685) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with in vitro IC50 of 0.86 nM, and SPR Kd of 0.68 nM.
PF-07247685 exhibits potent inhibitory potency in human skeletal myocytes using an AlphaLISA SureFire Ultra detection system to monitor BCKDH phosphorylation (cellular IC50 =3.0  nM).
PF-07247685 demonstrates superior potency relative to BT2 (Cat. PC-49378, IC50=1100 nM in vitro).
PF-07247685 acutely lowers tissue BCAA/BCKA in HFD-fed mouse tissues, increases BDK protein levels.

Physicochemical Properties

M.Wt 380.46
Formula C21H20N2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(6-((1-ethylcyclopropyl)methoxy)pyridin-3-yl)thiazol-2-yl)benzoic acid

References

1. Rachel J Roth Flach, et al. Nat Commun. 2023 Aug 9;14(1):4812.

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